Multivariate analysis of the relationship between survival and the microstage of primary melanoma by clark level and breslow thickness

9073 Background: Melanoma incidence in the United States is expected to be 4.3% of all cancers in 2008. Cutaneous melanoma patients are at risk for second primary melanoma development. Our goal was to characterize the histopathologic features, risk factors, and patient survival for second primary melanoma. Methods: A review of the melanoma database established in 1971 at John Wayne Cancer Institute was conducted identifying patients with American Joint Committee on Cancer (AJCC) stage I and II cutaneous melanoma who later developed a second primary melanoma. Patients were grouped by Breslow thickness, Clark level, and histopathologic subtype (superficial spreading [SSM], nodular, acral lentiginous, lentigo maligna, and in situ). Multivariate analysis involving age, gender, Breslow thickness, Clark level, and ulceration status was performed to determine an effect on development of second primary. Kaplan-Meier survival curves were plotted for single primary and second primary melanoma patients. Results: Second primary melanoma was identified in 411 (3.7%) of 10,968 patients with AJCC stage I-II melanoma. The most common first primary subtype was SSM, and 93% of these patients had in situ or SSM as the second primary. Sixty-five percent of first primaries had a Breslow thickness of ≤1 mm, and 75% of second primaries had a thickness ≤1 mm. Forty-nine percent of first primaries had Clark level I or II, but 68% of second primaries had Clark level I or II. In multivariate analysis, only increasing age was significantly associated with the likelihood of second primary melanoma (p<0.0001). With increasing follow-up time the hazard ratio of second primary melanoma was 1.31 for every decade. Overall survival for second primary melanoma patients was better than for single primary patients (p<0.0001). Conclusions: Most second primary melanoma patients will have SSM or in situ, with a decreased Clark level and Breslow thickness. Contrary to expectations, patients developing second primary melanoma did not exhibit decreased overall survival. Increased follow-up time after first primary melanoma is a significant risk factor for second primary development, thus illustrating the importance of lifelong patient follow-up. No significant financial relationships to disclose.

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Blood pressure level and laboratory indicators of disease severity in patients with arterial hypertension and COVID-19

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.166 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

K Popov ◽

A Novitskiy ◽

Y Shvarts

Keyword(s):

Blood Pressure ◽

Multivariate Analysis ◽

Arterial Hypertension ◽

Negative Correlation ◽

Diastolic Pressure ◽

Negative Relationship ◽

Laboratory Parameters ◽

Acute Period ◽

Nonparametric Correlation ◽

The Relationship

Abstract Funding Acknowledgements Type of funding sources: None. Background. Many patients with COVID-19 suffer from arterial hypertension and have marked variations in blood pressure (BP) during the acute period of infection. The reasons for such changes are poorly understood. Purpose. To assess the relationship between the level of BP and the severity of changes in the main clinical and laboratory parameters in patients with arterial hypertension and with a moderate course of COVID-19 at the stage of the height of the disease. Materials and methods. The study included 86 hospitalized patients with verified coronavirus disease of moderate severity: 46 of them were male, the median age was 65 years. Patients received adequate hypertension therapy for a long time. After hospitalization, treatment was adjusted if necessary. The level of laboratory parameters in the acute period of the disease was determined, including the electrolytes, C-reactive protein (CRP), albumin, ferritin, general blood test, etc. BP measured daily. The relationship between laboratory parameters and BP level was evaluated by nonparametric correlation using the Spearman coefficient and multivariate analysis based on the "generalized nonlinear model". Results. In 67.44% of patients with hypertension, an elevated BP level (>140/90) was observed against the background of moderate COVID-19. There was a significant negative correlation between the levels of CRP and BP throughout the stay in the hospital, the most significant is the 5th day of hospitalization. At the same time, a slightly stronger relationship is observed with diastolic BP (r = -0.4425) than with systolic BP (r = -0.3525). A similar trend is observed in all BP measurements. Besides, a negative correlation was found between potassium levels and BP values. The strongest association of potassium levels is with systolic BP on the day of hospitalization (r = -0.4850) and diastolic pressure on the 1st day of hospitalization (r = -0.3561). Multivariate analysis confirmed independent and reliable "influence" of CRP (p = 0.00018) and potassium (p = 0.03921) as independent predictors of diastolic pressure. Conclusions. Most patients with hypertension and moderate COVID-19 have elevated BP levels. There is a statistically significant negative relationship between the values of BP and levels of CRP and potassium. The obtained data may correspond to the existing hypothesis about the significant role of the kinin–kallikrein system in the pathogenesis of COVID-19.

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Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure

Disease Markers ◽

10.1155/2014/796075 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Haiyun Yu ◽

Juanhui Pei ◽

Xiaoyan Liu ◽

Jingzhou Chen ◽

Xian Li ◽

...

Keyword(s):

Heart Failure ◽

Multivariate Analysis ◽

Sudden Cardiac Death ◽

Chronic Heart Failure ◽

Cardiac Death ◽

Independent Predictor ◽

All Cause Mortality ◽

Patient Prognosis ◽

The Relationship

The purpose of this study was to evaluate whether CC-AAbs levels could predict prognosis in CHF patients. A total of 2096 patients with CHF (841 DCM patients and 1255 ICM patients) and 834 control subjects were recruited. CC-AAbs were detected and the relationship between CC-AAbs and patient prognosis was analyzed. During a median follow-up time of 52 months, there were 578 deaths. Of these, sudden cardiac death (SCD) occurred in 102 cases of DCM and 121 cases of ICM. The presence of CC-AAbs in patients was significantly higher than that of controls (bothP<0.001). Multivariate analysis revealed that positive CC-AAbs could predict SCD (HR 3.191, 95% CI 1.598–6.369 for DCM; HR 2.805, 95% CI 1.488–5.288 for ICM) and all-cause mortality (HR 1.733, 95% CI 1.042–2.883 for DCM; HR 2.219, 95% CI 1.461–3.371 for ICM) in CHF patients. A significant association between CC-AAbs and non-SCD (NSCD) was found in ICM patients (HR = 1.887, 95% CI 1.081–3.293). Our results demonstrated that the presence of CC-AAbs was higher in CHF patients versus controls and corresponds to a higher incidence of all-cause death and SCD. Positive CC-AAbs may serve as an independent predictor for SCD and all-cause death in these patients.

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Family involvement, adolescent self-concept and academic achievement

European Journal of Investigation in Health, Psychology and Education ◽

10.3390/ejihpe5030027 ◽

2015 ◽

Vol 5 (3) ◽

pp. 293-311

Author(s):

Ana Álvarez ◽

Natalia Suárez ◽

Ellián Tuero ◽

José C. Núñez ◽

Antonio Valle ◽

...

Keyword(s):

Academic Achievement ◽

Multivariate Analysis ◽

Parental Involvement ◽

Family Involvement ◽

Significant Relationship ◽

Study Data ◽

Self Concept ◽

First Year ◽

Achievement Scores ◽

The Relationship

The purpose of this work was to analyze the specific relationship between parental involvement, dimensions of student self-concept and achievement. 503 students of Secondary Education (ESO) and the first year of Baccalaureate course participated in the study. Data were collected using two questionnaires (Family Involvement Questionnaire and Self-Concept Scale for Adolescents) and academic achievement scores. Data were analyzed using multivariate analysis of variance and paths analysis. The results obtained suggest a significant relationship between the dimensions of perceived family involvement and the dimensions of self-concept (except for parents' praise behaviors). What's more, the relationship between perceived family involvement and achievement is partially mediated by the academic self-concept.

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Association of Heavy Metals with Overall Mortality in a Taiwanese Population

10.21203/rs.3.rs-277882/v1 ◽

2021 ◽

Author(s):

Yi-hsueh Liu ◽

Chih-Wen Wang ◽

Da-Wei Wu ◽

Wen-Hsien Lee ◽

Ying-Chih Chen ◽

...

Keyword(s):

Heavy Metals ◽

Multivariate Analysis ◽

General Population ◽

Confidence Interval ◽

Health Issues ◽

Taiwanese Population ◽

Southern Taiwan ◽

The Relationship ◽

Overall Mortality

Abstract Previous studies have shown links between heavy metals and many health issues. However, data on the association between heavy metals and mortality in the general population are still limited. Therefore, the aim of this study was to investigate the relationship between heavy metals and overall mortality in the general population. We enrolled 2,497 participants (1,001 males and 1,496 females) living in southern Taiwan, and measured levels of seven heavy metals: lead (Pb) in blood and cadmium (Cd), nickel (Ni), copper (Cu), chromium (Cr), manganese (Mn) and arsenic (As) in urine. The median follow-up period was 41.8 (4-50) months, during which 40 (1.6%) patients died. Compared to the participants who survived, those who died had higher urine Cd, higher urine Cu and lower urine Mn levels. Multivariate analysis showed that high urine Cd (per 1 mg/L; hazard ratio [HR], 1.352; 95% confidence interval [CI], 1.089-1.680; p = 0.006), high urine Cu (per 1 mg/dL; HR, 1.350; 95% CI, 1.151-1.583; p < 0.001), and low urine Mn (per 1 mg/L; HR, 0.717; 95% CI, 0.557-0.923; p = 0.010) were associated with increased overall mortality. In conclusion, our results demonstrated that high levels of urine Cd and Cu and low urine Mn level were associated with increased overall mortality in general population.

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KETERKAITAN SUBSISTEM AGRIBISNIS ITIK ALABIO PETELUR DI KABUPATEN HULU SUNGAI UTARA PROVINSI KALIMANTAN SELATAN (The Relationship Between Agribusiness Subsystems of The Alabio Layer Ducks In Hulu Sungai Utara District South Kalimantan Province)

Indonesian Journal of Applied Sciences ◽

10.24198/ijas.v3i3.15051 ◽

2013 ◽

Vol 3 (3) ◽

Author(s):

Siti Erlina

Keyword(s):

Multivariate Analysis ◽

Hypothesis Testing ◽

Random Sampling ◽

Sampling Technique ◽

Maximum Level ◽

T Test ◽

Survey Method ◽

Stratified Random Sampling ◽

Marketing Costs ◽

The Relationship

AbstrakUsaha peternakan itik alabio di Kabupaten Hulu Sungai Utara belum berkembang sebagaimana mestinya ditunjukkan 80 persen peternak kepemilikannya dibawah 500 ekor. Pengembangan agribisnis itik alabio dengan memperhatikan semua subsistem menjadi penting agar diperoleh tingkat produksi dan pendapatan maksimal.Penelitian bertujuan untuk mengkaji keterkaitan antar subsistem agribisnis itik alabio petelur terhadap produksi dan pendapatan peternak. Penelitian menggunakan metode survey, penentuan sampel peternak memakai teknik stratified random sampling, sedangkan sampel pedagang, breeder dan pembesaran melalui teknik purposive. Hipotesis diuji dengan analisis multivariat, uji F dan uji T. Hasil penelitian menunjukkan pengembangan agribisnis melalui peningkatan produksi dapat dilakukan dengan memperhatikan sumber bibit, harga kandang, jumlah pakan, jumlah tenaga kerja dan biaya pemasaran, sedangkan melalui peningkatan pendapatan dengan memperhatikan sumber bibit, harga bibit, harga kandang, jumlah pakan dan biaya pemasaran. Secara bersama-sama semua subsistem menentukan namun secara parsial subsistem lembaga penunjang tidak menentukan tingkat produksi dan pendapatan peternak.Kata kunci : Kabupaten Hulu Sungai Utara, itik alabio, pengembangan gribisnis.AbstractAlabio duck farming businesses in Hulu Sungai Utara district have not yet been developed as it should be, it indicated that 80 percent of the owners farmers just owned under 500 ducks. Alabio duck agribusiness development with attention to all subsystems become important in order to obtain the maximum level of production and income. This research aimed to examine the linkages between agribusiness subsystems of Alabio duck layers . Research used a survey method with stratified random sampling technique, while the sample traders, breeders and growers by using purposive. The hypothesis testing analysis used multivariate analysis, F test and T test. The results showed, agribusiness development through increased production can be done with the source of female ducks, cages prices, the amount of feed, the amount of labor and marketing costs. While through increasing of revenue could be fulfilled by female duck sources, female duck price, price of the cage, the amount of feed and marketing costs. Together of all subsystems were crucial but in partial subsystems supporting institutions did not determine the level of production and income of the farmers. Keywords: Hulu Sungai Utara District, Alabio ducks , agribusiness development.

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Economic Growth, Public and Private Consumption in Cameroon: A Multivariate Analysis

IRA-International Journal of Management & Social Sciences (ISSN 2455-2267) ◽

10.21013/jmss.v11.n1.p3 ◽

2018 ◽

Vol 11 (1) ◽

pp. 26

Author(s):

Honoré Samuel NTAVOUA

Keyword(s):

Economic Growth ◽

Multivariate Analysis ◽

Empirical Research ◽

Private Consumption ◽

Causal Link ◽

Vector Model ◽

Public And Private ◽

Public Consumption ◽

The Relationship

<p>The nature of the link between economic growth, public and private consumption in theoretical and empirical research is not well known in Cameroon. The objective of this study is to examine the nature of the relationship between economic growth, public and private consumption in Cameroon from 1980 to 2015. In order to achieve our goal, the data from the CENUCED were collected and tested in the autoregressive vector model (VAR). The delay selection statistic for VAR allowed us to have the following causality results: in Cameroon, there is a unidirectional relationship between economic growth towards public consumption and economic growth towards private consumption. Meanwhile, there is no causal link between public and private consumption, from public and private consumption to economic growth. Thus, the recommendation is that the Cameroonian government should create an incentive framework conducive to the improvement of public and private consumption to stimulate investment and economic growth.</p>

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UNIVERSUM KELEMBAGAAN KESATUAN PENGELOLAAN HUTAN PRODUKSI (KPHP) MODEL KABUPATEN BANJAR PROVINSI KALIMANTAN SELATAN

JURNAL HUTAN PULAU-PULAU KECIL ◽

10.30598/jhppk.2016.1.2.143 ◽

2016 ◽

Vol 1 (2) ◽

pp. 143

Author(s):

Ridwan Sya’rani ◽

San Afri Awang ◽

Nunuk Supriyatno ◽

Ris Hadi Purwanto

Keyword(s):

Multivariate Analysis ◽

Forest Management ◽

Human Resources ◽

Structural Equation Model ◽

Structural Equation ◽

Sampling Method ◽

Sampling Technique ◽

Equation Model ◽

Institutional Variables ◽

The Relationship

This study aims to examine the relationship between the factors that forming the institutions in Production Forest Management Unit (KPHP) Model Banjar Regency, South Kalimantan Province. The analysis used is Structural Equation Model (SEM). SEM is a multivariate analysis were used to analyze the relationship between variables. The sampling technique was conducted using purposive sampling method with 83 respondents. Based on the results of the study showed that the institutionality is signicantly inuenced by the factors of human resources, institutional variables and linkage.

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